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The EU Commission cracks down on modern slavery and child sexual abuse
The European Commission has today adopted two proposals for new rules to step up the fight against trafficking in human beings and child sexual abuse, sexual exploitation and child pornography. These new proposals replace existing legislation which has been in place since respectively 2002 and 2004. The new proposals will guarantee full alignment with the highest European standards, provide better assistance for victims and tougher action against criminals responsible for child sexual abuse and trafficking. The proposals also deal with the rapidly changing technologies in the cyberspace
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Keratinocyte Growth Factor Receptor Restores 5-Fluorouracil and Tamoxifen Efficacy on Resp
Silencing of Keratinocyte Growth Factor Receptor Restores 5-Fluorouracil and Tamoxifen Efficacy on Responsive Cancer Cells.Sabrina Rotolo 1, Simona Ceccarelli 1, Ferdinando Romano 1, Luigi Frati 1,2, Cinzia Marchese 1, Antonio Angeloni 1* 1 Dipartimento di Medicina Sperimentale, Universita` Sapienza di Roma, Roma, Italy, 2 Istituto Neurologico Mediterraneo ‘‘Neuromed, Pozzilli, ItalyAbstract : BackgroundKeratinocyte growth factor receptor (KGFR) is a splice variant of the FGFR2 gene expressed in epithelial cells. Activation of KGFR is a key factor in the regulation of physiological processes in epithelial cells such as proliferation, differentiation and wound healing. Alterations of KGFR signaling have been linked to the pathogenesis of different epithelial tumors. It has been also hypothesized that its specific ligand, KGF, might contribute to the development of resistance to 5-fluorouracil (5-FU) in epithelial cancers and tamoxifen in estrogen-positive breast cancers.Abstract : Methodology/Principal FindingsSmall interfering RNA was transfected into a human keratinocyte cell line (HaCaT), a breast cancer derived cell line (MCF-7) and a keratinocyte primary culture (KCs) to induce selective downregulation of KGFR expression. A strong and highly specific reduction of KGFR expression was observed at both RNA (reduction = 75.7%, P = 0.009) and protein level. KGFR silenced cells showed a reduced responsiveness to KGF treatment as assessed by measuring proliferation rate (14.2% versus 39.0% of the control cells, P
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Jef Raskin, Mac pioneer, dies at 61
Pacifica, CA February 27, 2005--Jef Raskin, a mathematician, orchestral soloist and composer, professor, bicycle racer, model airplane designer, and pioneer in the field of human-computer interactions, died peacefully at home in California on February 26th, 2005 surrounded by his family and loved ones. He had recently been diagnosed with pancreatic cancer.
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Stem-cell 'secret of youth' found
Chemical might help human cells reach clinic. ERIKA CHECK
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THE FANCONI ANAEMIA/BRCA PATHWAY
Fanconi anaemia (FA) is a rare genetic cancer-susceptibility syndrome that is characterized by congenital abnormalities, bone-marrow failure and cellular sensitivity to DNA crosslinking agents. Seven FA-associated genes have recently been cloned, and their products were found to interact with well-known DNA-damage-response proteins, including BRCA1, ATM and NBS1. The FA proteins could therefore be involved in the cell-cycle checkpoint and DNA-repair pathways. Recent studies implicate the FA proteins in the process of repairing chromosome defects that occur during homologous recombination, and disruption of the FA genes results in chromosome instability ”€ a common feature of many human cancers.
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